Dilatation of the coronary arteries also occurs. Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure and mean arterial pressure (afterload). Dilatation of the veins promotes peripheral pooling of blood, decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload). The principal pharmacological action of ISMN and all organic nitrates in general is relaxation of vascular smooth muscle, producing dilatation of peripheral arteries and veins, especially the latter. The isosorbide mononitrate extended-release tablet is an oral extended-release formulation of ISMN, the major active metabolite of isosorbide dinitrate most of the clinical activity of the dinitrate is attributable to the mononitrate. Isosorbide mononitrate is freely soluble in water, ethanol, methanol, chloroform, ethyl acetate, and dichloromethane.įor 60 mg and 120 mg: Meets USP Dissolution Test 1. ISMN is a white, crystalline, odorless compound which is stable in air and in solution, has a melting point of about 90☌, and an optical rotation of +144° (2% in water, 20☌). The chemical name for ISMN is 1,4:3,6-dianhydro-,D-glucitol 5-nitrate the compound has the following structural formula: The molecular formula of ISMN is C6H9NO6 and the molecular weight is 191.14. In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, diethyl phthalate, hydrogenated castor oil, hydroxypropyl cellulose, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, talc and titanium dioxide. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist.Isosorbide mononitrate (ISMN), an organic nitrate and the major biologically active metabolite of isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins.Įach tablet, for oral administration, contains either 30 mg, 60 mg or 120 mg of isosorbide mononitrate in an extended-release formulation. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Neither Everyday Health nor its licensor assume any responsibility for any aspect of healthcare administered with the aid of the information provided. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. The drug information above is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. Neither Everyday Health nor its licensors endorse drugs, diagnose patients or recommend therapy. The information on this page has been compiled for use by healthcare practitioners and consumers in the United States and therefore neither Everyday Health or its licensor warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drug information contained herein may be time sensitive. Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen.Įvery effort has been made to ensure that the information provided by on this page is accurate, up-to-date, and complete, but no guarantee is made to that effect. This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis. You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition.
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